Ryoji Noyori Prize
Professor Tsuneo Imamoto
Professor Emeritus, Chiba University & Visiting Professor, Hokkaido University, Japan.
Professor Imamoto is a pioneer in the use of phosphine–boranes for the synthesis of chiral phosphine ligands. He designed and synthesized many new P-chiral phosphine ligands and demonstrated their superior performance in asymmetric catalysis. The air-stable P-chiral phosphine ligand QuinoxP* is widely used in both academia and industry. He also made significant contributions to the mechanistic studies of rhodium-catalyzed asymmetric hydrogenation in collaboration with Professor Ilya D. Gridnev. Another outstanding achievement is the development of cerium(III)-modified organometallic reagents, which have found widespread use in the efficient addition reactions of carbonyl compounds.
What’s the Ryoji Noyori Prize ?
- Ryoji Noyori Prize sponsored by Takasago International Corporation (Administered by the Society of Synthetic Organic Chemistry, Japan )
- To recognize and encourage outstanding contributions to research in asymmetric synthetic chemistry defined in its broadest sense.
- The Prize consists of a certificate, an ornament, and $10,000. The recipient shall deliver a prize lecture at the annual general meeting of the Society of Synthetic Organic Chemistry, Japan (SSOCJ) at which time the prize will be presented. The travel expenses to the Meeting will be paid.
- Establishment and Support
- The prize was established by SSOCJ in 2002 to commemorate Ryoji Noyori’s winning distinction of the 101st Nobel Prize in Chemistry as well as the 60th anniversary of SSOCJ and is sponsored by Takasago International Corporation.
- Rules of Eligibility
- The Prize shall be granted to an individual without regard to age or nationality for the outstanding achievement in the field of asymmetric synthetic chemistry defined in its broadest sense.
- Any individual may submit only one nomination form in any given year.
The documents are retained on file for three prize-years.
- An international prize committee selects the recipient. The Committee consists of seven appointed members [four from Japan, including an academic vice president of SSOCJ (chairperson) and three from abroad]. These appointments are made by the President of SSOCJ.
Past Ryoji Noyori Prize Recipients
Professor Scott E. Denmark
Reynold C. Fuson Professor of Chemistry at the University of Illinois at Urbana-Champaign, U.S.A.
Professor Denmark has pioneered the concept of chiral Lewis base activation of Lewis acids for catalysis with Main Group elements. He has also developed palladium-catalyzed cross-couplings with organofunctional silicon compounds and mechanistic studies on the Suzuki-Miyaura cross coupling. In recent years, his group has investigated the use of chemoinformatics and machine learning to identify and optimize catalysts for enantioselective reactions. Earlier contributions include the development and application of tandem heterodiene cycloadditions for the synthesis of complex natural and unnatural nitrogen containing compounds. He maintains a longstanding interest in organosilicon, -phosphorus, and –lithium chemistry.
Professor Yoshito Kishi
Morris Loeb Professor of Chemistry, Emeritus, Harvard University, U.S.A.
Professor Kishi has been engaged in a wide range of research on complex natural products with significant biological activities. He pioneered the area of acyclic stereocontrol, completed the total synthesis of numerous complex natural products including neurotoxins (palytoxin, tetrodotoxin, etc.), polyether antibiotics (monensin, lasalocid A, etc.) and antitumor natural products (halichondrins, mitomycin, etc.), and advanced a new concept for stereochemistry assignment of complex organic molecules. Notably, his research efforts on the halichondrin class of marine natural products paved the way for the successful creation of Eisai’s anticancer drug Halaven (Eribulin mesylate).
Professor David W. MacMillan
Department of Chemistry, Princeton University, U.S.A.
Professor MacMillan has been a pioneer in both the areas of organocatalysis and photoredox catalysis. Within organocatalysis he invented the area of iminium catalysis and made significant contributions to hydrogen-bonding catalysis, including the development of the MacMillan organocatalysts. He has also been a leader in bringing the field of photoredox catalysis to synthetic organic chemistry. This new area already has widespread applications in the pharmaceutical industry.
Professor Keiji Maruoka
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan
Professor Maruoka designed a series of chiral high-performance organocatalysts such as base, acid, bifunctional, and radical organocatalysts for asymmetric organocatalysis. His most important and significant achievement is the development of asymmetric phase-transfer chemistry by designing “Maruoka Catalyst®”.
Professor Larry E. Overman
Distinguished Professor, Department of Chemistry, University of California, Irvine, U.S.A.
Professor Overman and his coworkers have completed total syntheses of more than 100 structurally complex natural products using synthesis strategies developed largely in his laboratory.
Professor Dieter Enders
Seniorprofessor RWTH Aachen University, Germany
Professor Enders is a pioneer in the field of asymmetric synthesis. He has developed first broadly applicable chiral auxiliaries, such as SAMP/RAMP and demonstrated their efficiency in numerous natural product syntheses. He also established the field of asymmetric carbon – carbon bond formations catalyzed by N-heterocyclic carbenes and made seminal other contributions to the field of organocatalysis.
Professor Barry M. Trost
Stanford University, U.S.A. Job and Gertrud Tamaki Professor of Humanities and Sciences
Professor Trost characterized by a very high order of imagination, innovation and scholarship, has repeatedly led to the invention of new synthetic reactions and demonstrated their effectiveness by the design of new strategic approaches for the total synthesis of bioactive molecules and has made important contributions in evolving some of the concepts of green chemistry, notably atom economy.
Professor Masakatsu Shibasaki
Professor, Director of Institute of Microbial Chemistry (BIKAKEN) and Emeritus Professor: The University of Tokyo, Hokkaido University, Japan.
Professor Shibasakihas established the concept of cooperative asymmetric catalysis, developing many reactions with high atom economy. His accomplishments are also successfully highlighted in his catalytic asymmetric syntheses of bioactive compounds.
Professor Hisashi Yamamoto
Department of Chemistry, The University of Chicago, U. S. A.
Professor Yamamotowas pioneered the use of binaphthol as a key ligand for chiral Lewis acid catalysts, which was the forerunner of a C-2 symmetry based chiral acid catalyst. His combined Brønsted and Lewis acid catalysts are the most efficient among the asymmetric acid catalyst and his super Brønsed acid catalysts play an important role in the step-economical synthesis of complex molecules. He also introduced V, Zr, Hf, and Fe catalysts for asymmetric oxidation. These achievements have had a seminal impact in asymmetric synthesis.
Professor Eric N. Jacobsen
Department of Chemistry & Chemical Biology, Harvard University, U. S. A.
Professor Jacobsen discovered useful, chiral salen-based catalysts for asymmetric epoxidation of simple olefins, as well as effective new catalysts for aziridnation, Diels-Alder, conjugate addition, hydrocyanation, and epoxide ring-opening reactions. He also pioneered the use of hydrogen-bonding catalysts in asymmetric synthesis. These methodologies, together with the mechanistic insights he has uncovered about them, have had a profound impact both in academia and in industry.
Professor Yoshio Okamoto
Distinguished Invited University Professor, Nagoya University & Chair Professor, Harbin Engineering University
Professor Okamoto has made significant contribution to the areas of synthesis of helical polymers and their application to chiral separation of enantiomers. He was the first to succeed in the synthesis of one-handed helical polymer by asymmetric polymerization, and found its high chiral recognition ability to many racemic compounds. Using the polymer, he successfully developed a practical chiral packing material for HPLC. His another outstanding contribution is the development of very useful chiral packing materials based on helical polysaccharide derivatives, which are widely used throughout the world.
Professor Andreas Pfaltz
Department of Chemistry, University of Basel, Switzerland.
Professor Pfaltz is well known for his seminal contributions to asymmetric catalysis. The semicorrins developed in his group served as the prototype for an important new family of nitrogen ligands, the bisoxazolines, which have found widespread use in catalytic asymmetric synthesis. His work on phosphinooxazolines, known as PHOX ligands, has led to numerous efficient chiral transition metal catalysts. Most noteworthy are iridium-PHOX and related complexes, which are the first catalysts that allow highly enantioselective hydrogenation of unfunctionalized, purely alkyl-substituted olefins and, therefore, greatly enhance the scope of asymmetric hydrogenation.
Professor Tamio Hayashi
Department of Chemistry, Graduate School of Science, Kyoto University, Japan
Professor Hayashi is best known for his insightful and seminal contributions to the area of catalytic asymmetric synthesis, especially carbon-carbon bond forming reactions using chiral transition metal catalysts. He was the first to succeed in palladium-catalyzed asymmetric cross-coupling, gold-catalyzed asymmetric aldol-type reaction, and rhodium-catalyzed asymmetric addition reactions. His another outstanding contribution is the development of new and powerful chiral ligands. Chiral ferrocenylphosphines have been widely used for various types of asymmetric reactions, and the chiral dienes he designed recently are attracting particular attention as an unprecedented type of chiral ligands.
Professor David A. Evans
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, USA.
Professor Evans has made significant advances in the design of stereoselective reactions and the applications of these reactions to natural products synthesis. Especially enantioselective Diels-Alder, Michael, and aldol reactions are three of the important families of processes developed in his group. In the area of synthetic design, he has archieved synthesis of complex natural products through the exclusive use of chiral auxiliaries to control stereochemical relationships. Evans’ chiral auxiliaries and chiral catalysts for enantioselective bond formation are widely used in both industrial and academic laboratories throughout the world.
Professor Tsutomu Katsuki
Department of Chemistry, Faculty of Science, Graduate School, Kyushu University, Fukuoka, Japan
Professor Katsuki has been contributing to advancement of ecological asymmetric synthesis as a leading chemist, demonstrating the power of molecular catalysis comparable to that of enzyme. He has discovered asymmetric epoxidation of allylic alcohols in collaboration with Professor K. Barry Sharpless and recently reported asymmetric epoxidation of simple olefins using aqueous hydrogen peroxide. He first introduced chiral catalysts activated by photo-irradiation and realized various aerobic asymmetric oxidations
Professor Dieter Seebach
Laboratorium fur Organische Chemie, ETH Honggerberg, Switzerland
Professor Seebach has been serving as one of the top scientists more than four decades, creatingsa range of new concepts and paradigms in organic synthesis. His contributions have made ever-increasing impact not only on fundamental as well as practical organic synthesis, but also on various related fields, including material sciences and biochemical fields.
Professor Gilbert Stork
Department of Chemistry, Columbia University, New York, U.S.A.
Professor Stork has been leading the field of organic synthesis for over half a century. With his cantharidin synthesis and the Stork-Eschenmoser hypothesis of steroid synthesis in the 1950’s, he introduced the concept of “stereoselective organic synthesis” and created a number of fundamental synthetic methods such as enamine and enol silyl ether methodologies and radical cyclization. In 2001, he published the first completely stereoselective total synthesis of quinine.
Emeritus Professor Henri B. Kagan
Laboratoire de Synthese Asymetrique Universite Paris-Sud France
Professor Kagan has been a leader in the field of asymmetric synthesis, presenting many first examples including those of asymmetric synthesis using circularly polarized light, a chiral bidentate diphosphine ligand (DIOP), and a chiral “homogeneous” supported catalyst.